Cytotoxic constituents from Butea superba Roxb.

Ngamrojanavanich, Nattaya; Loontaisong, Aimon; Pengpreecha, Somchai; Cherdshewasart, Wichai; Pornpakakul, Surachai; Pudhom, Khanitha; Roengsumran, Sophon; Petsom, Amorn

https://doi.org/10.1016/j.jep.2006.07.034

Abstract

A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC50 (µM) values of 37.3 ± 2.5 and 71.1 ± 0.8 and on BC cell lines with IC50 (µM) values of 32.7 ± 1.5 and 47.3 ± 0.3, respectively.

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